This is an interesting article about how scientists are using marine biology to help find new drugs to fight cancer. Remember, your postings should never be copied, always about a 1/2 page long ( you can use your word processing file to type it first, then past it into the blog). Try to focus on the key points as if you were going to explain it to your family. Include the molecular makeup and how scientists think it'll work on cancer cells.
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Scientists are now using mud from the ocean to treat cancer in humans. There is a marine bacterium that incorporates a chlorine atom, which is the key ingredient for triggering its potent cancer-fighting product. This is the first time that chlorinated natural products have worked. The derivative “salinosporamide A” of Salinispora is presently in phase one for human clinical trials for the treatment of multiple cancers. Moore and Scripps’ Daniel Udwary and their team discovered the genome of S. Tropica in June. Thus paving the way for new discoveries.
These new discoveries will be able to provide a “road map” for further development of cancer treatment drugs. Then with genetic engineering the development of second-generation compounds will be easier to create that can’t be found in nature.
The chlorine atom is the reason why the drug is so very effective against cancer. In find this enzyme it creates a new pathway for humans to understand how and why related enzymes are activated in different ways.
reserchers led by bradley Moore at UC san Diego, discovered an enzyme called Sall in Salinispora tropica, or a marine bacterium. this finding could lead to new treatments of human diseases. it has a key ingredient its potent cancer fighting natural product. it employs a substituion strategy that uses non-oxidized chlorine as it is found in nature like salt.
I think this new finding could really help people that have bad diseases. or even cancer and give them hope. this could chage medicin drasticly
The team of scientists in san diego led by Bradley Moore are finding a unexpected biological process that can have possible effects on helping treat cancer. They have discovered an enzyme called SaIL that is a marine bacterium that is very hopeful for treating human diseases. The chlorine atom is the triggering potent cancer fighter. "This was a totally unexpected pathway," said Moore. The non-oxidized chlorine is as common as table salt. It is in the phase of the clinical trials for myeloma and other cancers. This is truly amazing that this can help pave the way to solving and treating cancer and possibly other diseases. The Mud in the ocean is taking us in the new age of science and new discoveries.
A discovery from UC San Diego has possibly found a cancer fighting organism that could be very useful to humans. It also could help out with curing various other diseases. This marine bacterium was identified in 1991 by Scripps researchers and finally being put to use! The bacterium has a key cancer fighting atom called the chlorine atom. This won't be an oxygen based approach unlike the past though. It will now be approached as it is in nature. It is now in phase 1 of the testing trials and could lead to second generations compounds not found in nature. How cool is that!
reserchers from UC san Diego led by bradley Moore discovered a cancer fighting organism called Sall in Salinispora tropica, or a marine bacterium. this could lead to new treatments of human diseases like cancer. Sall in Salinispora tropica uses non-oxidized chlorine thats found in nature like salt.
I think this new discovery could really help people that have cancer and other bad diseases,and give them hope.
"As scientists describe in a recent issue of Nature Chemical Biology, the researchers identified a "pathway" for the way the marine bacterium incorporates a chlorine atom, the key ingredient for triggering its potent cancer-fighting natural product." This is very interesting how scientists find different things in underwater living life! Also, "salinosporamide A," of Salinispora is in phase one for human clinical trials for the treatment of multiple cancers. That is awesome !!
A research team discovered an enzyme called SalL inside Salinispora tropica, a promising marine bacterium identified in 1991 by Scripps researchers. To find a cure for cancer is one thing, but from a natural resource thats from the ocean? Thats pretty crazy, it must be pretty hectic trying to come up with cures for cancer and see which ones actually effect against it.
bradley Moore at UC san Diego and his fellow researchers discovered an enzyme called Sall in Salinispora tropica, or a marine bacterium. this could lead to new treatments of cancer and other diseases. it has an ingredient in it that is a potent cancer fighting natural product. Scientists are now using ocean mud to treat certain cancers in people. the marine bacterium found in this ocean mud contains a chlorine atom which is needed to t rigger its potent cancer fighting product. this is a new and completely unexpected pathway and could lead to many other new ocean discoveries that could help fight off human diseases. this is truly an amazing concept that there is a possibility people can find a cure for cancer inside something like ocean mud.
A group of scientists led by Bradley Moore of UCSD are have discovered that ocean mud is able to fight diseases such as cancer in humans. There is marine bacterium in the mud that builds a chlorine atom, which is the key ingredient for triggering its potent cancer fighting product. This is the very first time mud has ever been used for this and it is also the first time that chlorinated natural products have been successful. The chlorine atom is the reason why this is so affective against fighting cancer. The Salinosporamide A is in phase one for human clinical trials of the treatment of almost all cancers. Bradley Moore and his team are going back in more tropical places in summer of 2009 for more research and for more discoveries.
Marine Biologists at Scripps Institution of Oceanography at UC San Diego found information about a marine organism that creates a natural product currently being tested to treat cancer in humans. This unique enzyme is called SalL, which is inside Salinispora tropica, a marine bacterium. The marine bacterium has a chorine atom, which is the key ingredient for triggering its cancer- fighting natural product. The new method so far has been more successful because it uses non- oxidized chlorine as it is found in nature, such as common table salt. The Salinispora original “salinosporamide A” is currently in phase one human clinical trials for the treatment of multiple myeloma and other cancers. Knowing how the natural product is made biologically may help scientists manipulate key molecules to engineer new versions of Salinispora- derived drugs. Chlorine is a major component of seawater and also a fundamental component of Salinispora’s disease inhibiting abilities. Finding the enzyme and its new pathway also helps understand evolutionary development. We can only hope that these new marine products can help prevent and eliminate diseases in the world.
There was a research led by Bradley Moore, who is the professor with UCSD's Scripps Oceanography Center for Marine Biotechnology and Biomedicine. Along side him was researcher Alessandra Eustáquio, they discovered an enzyme called SalL inside Salinispora tropica, a promising marine bacterium which was found in 1991.
They said in a recent issue of Nature Chemical Biology the researchers also identified a novel process-a "pathway"-for the way the marine bacterium incorporates a chlorine atom, the key ingredient for triggering its potent cancer-fighting natural product. Previously known methods for activating chlorine were processed through oxygen-based approaches. The new method, on the other hand, employs a substitution strategy that uses non-oxidized chlorine as it is found in nature, as with common table salt.
The Salinispora derivative "salinosporamide A" is currently in phase I human clinical trials for the treatment of multiple myeloma and other cancers. A team led by Moore and Scripps' Daniel Udwary solved the genome of S. tropica in June, an achievement that helped pave the way for the new discoveries.They claim it is unclear how pervasively SalL and its unique biological activation pathway exist in the ocean environment. Chlorine is a major component of seawater, and, according to Moore, a fundamental component of Salinispora's disease-inhibiting abilities."The chlorine atom in salinosporamide A is key to the drug's irreversible binding to its biological target and one of the reasons the drug is so effective against cancer," said Moore.
A discovery was made at Scripps Institution of Oceanography at UC San Diego about a potential treatment of cancer. The research team was led by Bradley Moore. A new way for the activation chlorine which helps fight cancer was found. Non-oxidized chlorine is found in nature and the new method would use this naturally found chlorine to fight cancer. Figuring out how the chlorine is made in nature can also help the scientists come up with more medicines. The marine bacterium incorporates a chlorine atom and triggers the chlorine. The marine bacterium is found in ocean mud. I think it is cool that scientists can now use ocean mud to find ways to treat and fight cancer.
Bradley Moore leads a team of researchers at UCSD to discover ways to treat cancer. From mud, they have found bacteria that contains the enzyme sall. this chlorine atom is a definite cancer fighter. This enzyme is very common, and can therefore be mass produced for beneficial purposes to hospital patients. Salinispora Tropica is the bacteria that this enzyme derives from. Scripps researchers first found it in 1991, and have finally found productive use for it. Using genetic engineering, they will be able to mass produce it and duplicate the enzyme with its effects. This natural solution to a human disease is environmentally friendly and comes from our backyards- the ocean! i cant wait to hear about further progress in this exciting research!
of course this "unexpected discovery" is found at Scripps Institution of Oceanography at UC San Diego! marine biomedical laboratories currently found some new information about the inside of a marine organism that could help us medically. How? it could treat cancer!Bradley Moore along with Alessandra Eustaquio led the research team that discovered an enzyme known as SalL inside Salinispora tropica. inside SalL there seems to be a "pathway" helping trigger its cancer-fighting natural product. over 2,000 chlorinated natural products had been researched but none showed such a "pathway" as this one according to Moore. not only could this new discoverey lead to further potential for drug development on Salinispora tropica's side, but also provide a treatment for cancer such as myeloma.
i forgot to add how the chlorine atom in this enzyme has an irreversible binding to its target say for instance--CANCER!
Mud from the ocean is now being used to treat cancer in humans. It was Daniel Udwary and his team discovered the genome of s. Tropica in June. This has opened new doors for discoveries. It happens to be the chlorine atom that makes it so effective against cancer. This is a great discovery, we need more treatments for cancer.
Bradley Moore and his research team, along with Alessandra Eustáquio have discovered an enzyme called SaIL inside Salinispora tropica. This discovery has had promising results and could potentially be used to treat cancer. It involves a new method of activating chlorine different from previous methods that were processed through oxygen-based approaches. The new method uses a substitution strategy that uses non-oxidized chlorine that is found in nature. If they are able to figure out how chlorine is made in nature they would be able to come up with new versions of Salinispora-derived drugs. This could also lead to second generation compounds not found in nature. The chlorine atom in salinosporamide A is the reason that the drug binds irreversibly to its biological target which makes it so effective against cancer.
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